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The final proposed mechanism of RBC vasodilation while in the presence of nitrite may be the reduction of nitrite to NO by Hb. Brooks first analyzed the nitrite Hb interaction in 1937 which do the job was later on extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to form metHb and NO (Brooks, 1937; Do